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Nuova caratterizzazione immunofenotipica del melanoma sottile. Correlazione con i parametri anatomo-patologici e con la prognosi di malattia
(Universita degli studi di Salerno, 2017)Nell’ambito dei melanomi meritano una menzione particolare i cosiddetti melanomi sottili, di spessore ≤1 mm che, sebbene caratterizzati da un’altissima percentuale di guarigione dopo semplice escissione chirurgica, sono ... -
Profilo microbiomico e metabolomico in soggetti con anoressia nervosa prima e dopo recupero di peso: un approccio multi-omico
(Universita degli studi di Salerno, 2022-05-31)Sebbene l'eziopatogenesi dell'Anoressia Nervosa (AN) non sia ancora del tutto nota, tra i possibili meccanismi patogenetici sono state proposte le alterazioni dei sistemi di regolazione dell'alimentazione. Recentemente, ... -
La Sicurezza in Ospedale: dalla tradizione all’innovazione. Elaborazione di un piano di intervento multimodale per la riduzione del rischio infezioni nosocomiali
(Universita degli studi di Salerno, 2022-03-16)La sanità in Italia occupa più del 7% del Prodotto Interno Lordo nazionale (PIL) ed in media rappresenta circa l’80% dei bilanci regionali. Questi due semplici dati, in un contesto di evidente progressione dell’invecchiamento ... -
Circulating sortilin level as a potential biomarker for endothelial dysfunction and hypertension
(Universita degli studi di Salerno, 2022-03-16)Sortilin has been positively correlated with vascular disorders in humans. Previous studies showed that sortilin promotes activation of acid sphingomyelinase (ASMase) and subsequently induces an increase of nicotinamide ... -
Post-transcriptional gene regulatory networks in chronic airway inflammation: role of RNA-binding proteins
(Universita degli studi di Salerno, 2020-05-06)Background. RNA-binding proteins (RBPs) play a key role in post-transcriptional gene regulation (PTGR) of genes involved in numerous biological processes. These proteins act through the binding to specific cis-elements ... -
Opportunità e rischi della longevità. Aspettative presenti e future dal punto di vista epidemiologico, ecologico, medico e sociale, soprattutto sulla base dell’esperienza dei medici
(Universita degli studi di Salerno, 2021-06-15)Longevity is considered one of the greatest achievements of modern society. "Staying young forever" seems to be the new trend: Downgrading (i.e. being younger today than at the same age in the past) shows that there are ... -
Clinical characterization, genetic screening and genotype-phenotype associations in cerebellar and brainstem congenital defects
(Universita degli studi di Salerno, 2020-10-01)Cerebellar and brainstem congenital defects (CBCDs) represent a wide spectrum of malformative disorders resulting from abnormal development of midbrain-hindbrain and characterised by high clinical and genetic heterogeneity. ... -
Oncovigilanza e counseling farmacogenetico: strumenti per migliorare l'appropriatezza prescrittiva e la compliance dei pazienti oncologici in trattamento con fluoropirimidine in regione Campania
(Universita degli studi di Salerno, 2021-06-21)Fluoropyridines (FP) are used in the treatment of solid tumors and are frequently associated with severe Adverse Drug Reactions (ADR). It is recommended to analyse four Single Nucleotide Polymorphisms (SNPs) of the DPYD ... -
Umanizzazione della gestione integrata del bambino in ospedale: studio di valutazione dell’esistente e del percepito
(Universita degli studi di Salerno, 2021-05-11)Humanization of pediatric care (HC) provides for assistance centered not only on the child-patient but also on the whole family. The literature lacks of studies concerning the benefits obtained by patients and operators ... -
Integrated approach in Human Biomonitoring: epigenetic profile for environment-health study correlation
(Universita degli studi di Salerno, 2021-05-18)Human Biomonitoring (HB) represents a useful tool to investigate the complex relationship existing between environment and health. Assess human exposure to external stressors means to deepen observe, with a holistic approach, ... -
Studying the "neural behavior": a perspective on bridging the gap between behaviorism and neuroscience and its applications to language teaching strategies
(Universita degli studi di Salerno, 2021-07-09)The purpose of my thesis is to point out the development of a particular line of research aimed at bridging the gap between the Neurosciences and Behavior Analysis, the science of behavior and learning, by studying verbal ... -
Development of a bioengineered three-dimensional scaffold able to commit stem cells toward tenogenic phenotype
(Universita degli studi di Salerno, 2021-06-23)The term tendinopathy is a generic descriptor of tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis, with impaired biological and mechanical properties. Adult tendons have a ... -
Parodontite e carcinoma del colon-retto: la possibile associazione genetica e patogenetica
(Universita degli studi di Salerno, 2021-04-29)Base di partenza scientifica e razionale: Il carcinoma del colon-retto (CRC) è una neoplasia maligna molto comune, caratterizzata da un’incidenza stimata intorno al 9-10% ed una mortalità del circa 8-9% (700.000 morti/anno). La ... -
Espressione genica indotta dall'ormone somatotropo nei monociti di bambini sani e con deficit di GH
(Universita degli studi di Salerno, 2020-07-13)Somatotropic hormone (GH) has transcriptional effects on the cells of many organs, directly by activating its receptor (GHR) or indirectly through induction of IGF-1 or other mediators. The presence of GHR in almost all ... -
Role of vitamin D in the modulation of chronic bowel inflammation and in the genesis of bone mass loss in patients with inflammatory bowel diseases
(Universita degli studi di Salerno, 2020-07-09)Background: Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn’s disease (CD). Bone ... -
Cognitive and behavioral features in atypical parkinsonian syndromes
(Universita degli studi di Salerno, 2020-08-14)Introduction Progressive supranuclear palsy (PSP), Multiple system atrophy (MSA), corticobasal degeneration (CBD) and dementia with Lewy Bodies (DLB) are included in atypical parkinsonisms (AP) and they typically involve ... -
Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis
(Universita degli studi di Salerno, 2021-05-07)Introduction: Non-Alcoholic Fatty Liver Disease encompasses a spectrum of diseases ranging from simple steatosis to steatohepatitis (or NASH), up to cirrhosis and hepatocellular carcinoma(HCC). The challenge is to recognize ... -
Functional and metabolic brain correlates in hearing loss and rehabilitation
(Universita degli studi di Salerno, 2021-04-19)The human auditory system serves the role of extracting information from objects in the environment engaging in analyses of the auditory world so that the listener can accomplish the goal of learning and communication. ... -
Development and validation of analytical methods for therapeutic drug monitoring
(Universita degli studi di Salerno, 2019-07-25)The U.S. Food and Drug Administration defines as Precision or Personalized Medicine (PM) an innovative therapeutic approach that tailors therapy and prevention on patients based on inter-individual variabilities in molecular ... -
“Transcutaneous laryngeal ultrasonography: a reliable, non-invasive and inexpensive preoperative method in the evaluation of vocal cords motility. A prospective multicentric analysis on a large series and an analysis of Literature”
(Universita degli studi di Salerno, 2019-07-24)INTRODUCTION Benign and malignant thyroid diseases affect a large population worldwide. Total Thyroidectomy is one of the most commonly performed intervention in general surgery. The most feared and dangerous complication ...
