Area Scienze mediche: Recent submissions
Now showing items 101-120 of 171
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Study of the mechanism of action of bioactive plants tarpenoids
(Universita degli studi di Salerno, 2016-05-06)Natural products are small-molecule secondary metabolites displaying considerable structural complexity and “privileged scaffolds”. They are able to bind several endogenous targets eliciting biological effects as chemical ... -
Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ... -
New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(Universita degli studi di Salerno, 2016-03-16)The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ... -
Integrated metabolomics approaches for berry fruit used in nutraceutical formulations
(Universita degli studi di Salerno, 2016-04-13)The species under investigation during these three years of PhD course were: Fragaria ananassa, Fragaria vesca, Morus alba, Morus nigra and Myrtus communis. All these species are characterized by the production of small ... -
Trattamento delle fratture blow-out dell’orbita: endoscopia versus chirurgia tradizionale
(Universita degli studi di Salerno, 2016-05-04)In the last decades, diagnostical imaging, surgical techniques, alloplastic materials, and surgical instruments development, allowed a great progress in management of orbital fractures. The aim of the present study was to ... -
Translational pharmacogenomics: a study of warfarin dosing
(Universita degli studi di Salerno, 2016-04-21)Warfarin is one of the most commonly used oral anticoagulants worldwide and is highly efficacious for the treatment and prevention of thromboembolic disorders. However, due to its narrow therapeutic index, large inter-individual ... -
Nuove prospettive terapeutiche del glioma: N6-isopenteniladenosina ed SR141716
(Universita degli studi di Salerno, 2016-03-04)Glioma is a fatal disease characterized by uncontrolled cellular proliferation and it is the most common primary brain malignancy in adults. Despite years of research, malignant glioma remains one of the most aggressive ... -
Antioxidative and antisenescent effects of cardiac rehabilitation in heart failure patients
(Universita degli studi di Salerno, 2016-04-26)Exercise-based cardiac rehabilitation (CR) is effectively used as an adjuvant therapy in a number of cardiovascular diseases (CVDs), including chronic heart failure (CHF), and it is recommended by the American and European ... -
Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(Universita degli studi di Salerno, 2016-04-21)A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ... -
La Pentraxina 3: un potenziale marcatore di danno endoteliale nell’ipertensione arteriosa
(Universita degli studi di Salerno, 2016-04-26)Background - The pentraxin 3 (PTX3) is a protein of the acute phase of inflammation which represents the prototype of the long pentraxins. In the last years, numerous studies have correlated the elevated plasma levels of ... -
Essential Infantile Esotropia with Inferior Oblique hyperfunction and Lateral Recti pseudoparalysis: long term follow-up of 6 muscles approach
(Universita degli studi di Salerno, 2016-04-21)AIM: Analysis of long-term follow-up (3 months, 2 years, 5 years and 10 years) in Infantile Esotropia patients (IE), after a 6 muscles approach. METHODS: A 6 muscles approach in IE has been evaluated in patients with ... -
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(Universita degli studi di Salerno, 2016-05-04)The design of new metal complexes as anticancer agents has received considerable interest in recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.: texaphyrrins lanthanide) and ... -
Progettazione di un biosensore ottico per la determinazione atmosferica del benzene
(Universita degli studi di Salerno, 2016-04-15)In recent years, environmental pollution, particularly air pollution, is a subject of great scientific and public interests. The reason is due to the strong impact on human health. Air pollution is due to the placing in ... -
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ... -
Regolazione epigenetica dell’espressione del fattore peptidico gastrointestinale TFF1
(Universita degli studi di Salerno, 2016-04-19)TFF1 is a protein expressed in the gastrointestinal tract, belonging to the trefoil folding factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a cloverleaf disulfide ... -
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(Universita degli studi di Salerno, 2016-04-20)The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ... -
Transcriptional regulation of biosynthetic genes of the plant MEP-derived pathway to boost the metabolic flux towards bioactive diterpenes
(Universita degli studi di Salerno, 2016-02-02)This project was aimed at enhancing the synthesis of tri-cyclic bioactive abietane diterpenes (e.g. aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol), synthesized in the roots of Salvia sclarea and other Salvia ... -
Neuroimmune regulation of JCV by immune mediators in glial cells
(Universita degli studi di Salerno, 2015-04-23)The human polyomavirus JC (JCV) is a small DNA virus responsible for the initiation of progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes ... -
Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina
(Universita degli studi di Salerno, 2015-04-22)Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it may be a consequence of a reduced availability of this hormone, of an impediment to its normal action, or of a combination of ... -
Analisi funzionale del gene UVR8 e suo ruolo nella risposta delle piante a stress ambientali
(Universita degli studi di Salerno, 2015-07-16)Plants are sessile organisms and, therefore, are continuously subjected to environmental sub-optimal or stressful conditions. In an arid environment plants are challenging multiple stresses, such, as water shortage, excessive ...