Area Scienze mediche: Recent submissions
Items 61-80 di 171
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Functional Characterization of Candida albicans Hst3p histone deacetylase
(Universita degli studi di Salerno, 2019-05-07)The unicellular eukaryotic organism Candida albicans is one of the most important fungi in medicine, used as experimental model to study fungal pathologies and the underlying biology of dimorphic fungi. This fungus is a ... -
Technologies for the development of health products based on up-cycling of agro-food by-products
(Universita degli studi di Salerno, 2019-04-12)The agro-industrial processing produces large volumes of wastes and by-products. In recent years, wastes and by-products have attracted attention as an excellent renewable source of active compounds with beneficial effects ... -
The Winnie-APCmin as an innovative tool to investigate the axis between inflammation and colorectal cancer
(Universita degli studi di Salerno, 2019-05-07)During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ... -
Ruolo del Ruxolitinib nel cross-talk tra cellule staminali mesenchimali e microambiente midollare nella mielofibrosi
(Universita degli studi di Salerno, 2019-03-13)Introduction; Mesenchymal stem cells (Mesenchymal Stem Cells, MSC) are one of the most studied and well-characterized adult stem cell populations. They are excellent candidates in regenerative medicine, mainly because of ... -
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ... -
Design and synthesis of bioactive small molecules by traditional and innovative methods
(Universita degli studi di Salerno, 2018-03-28)My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ... -
Unraveling biomarkers in Parkinson’s disease: the role of Insulin-like growth factor-1 (IGF-1) and DAT imaging
(Universita degli studi di Salerno, 2018-02-28)Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting up to 10 million individuals worldwide. Although symptomatic treatment ameliorates motor symptoms, currently ... -
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ... -
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ... -
Chemical and biological study of natural substances active on the central nervous system
(Universita degli studi di Salerno, 2018-04-05)The research project "Chemical and biological study of natural substances active on the Central Nervous System" has been focused on the possible effects of essential oils, their main constituents (in particular monoterpenes), ... -
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ... -
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ... -
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)The normal heart rhythm is guaranteed by an important intercellular junctions system, named Gap Junction (GJs). Each GJs consists of two units called connexons formed by six specific trans-membrane proteins named connexins ... -
Computational design of new antimicrobial peptides
(Universita degli studi di Salerno, 2018-04-13)Antimicrobial peptides (AMP) are evolutionarily conserved components of the innate immune system. They have a broad spectrum of action against bacteria, fungi and viruses. Therefore, AMP are studied as probable substitutes ... -
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(Universita degli studi di Salerno, 2018-04-05)The inhalation therapy consists of a direct administration of drugs for the treatment of lung diseases. A formulation for inhalation is a valid option in the symptomatic management of pulmonary diseases typical of cystic ... -
Metabolic control of FoxP3 expression in human regulatory T cells
(Universita degli studi di Salerno, 2017-05-30)Regulatory CD4+CD25+ T (Treg) cells play a central role in the maintenance of immune self-tolerance and homeostasis. Although Treg cells operate through multiple mechanisms, it appears that the expression of the transcription ... -
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive extracts ... -
Creazione di modelli virtuali 3D da immagini TC e RM per la pianificazione degli interventi chirurgici in Chirurgia Pediatrica
(Universita degli studi di Salerno, 2017-05-23)BACKGROUND. Lo sviluppo di sistemi medicali sempre più avanzati per l’acquisizione delle immagini finalizzati all’estrazione di informazioni tridimensionali sugli organi del corpo umano tramite metodi non invasivi, hanno ... -
Rischio clinico, gestione del rischio e sue implicazioni. Un aspetto della medicina traslazionale
(Universita degli studi di Salerno, 2017-06-05)This thesis is based on the awareness that prevention in the ethical and vocational training of health workers is extremely important, above all the one concerned with the clinical risk as well as a competent and intelligent ... -
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...