Sfoglia Translational Medicine @ UniSa per Titolo
Items 1-20 di 284
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1,4-Dihydropyridines: the multiple personalities of a blockbuster drug family
(2012)More than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated ... -
18F-FDG PET and PET/CT in the localization and characterization of lesions in patients with ovarian cancer
(2012)Aim: The aim was to compare the imaging findings of 18F-fluorodeoxyglucose (18F-FDG) PET and integrated PET/CT in patients with primary, recurrent or metastatic ovarian cancer. Materials and methods. 21 women with ovarian ... -
Accelerated bone mass senescence after hematopoietic stem cell transplantation
(2013)Osteoporosis and avascular necrosis (AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation (HSCT). We describe the magnitude of bone loss, AVN and impairment in osteogenic cell ... -
Adrenergic mechanism in the control of endothelial function
(2011)There is considerable evidence that many disease are associated with endothelial dysfunction and reduced nitric oxide production such as hypertension, obesity, dyslipidemias, diabetes, heart failure, atherosclerosis. Notably ... -
Advanced applications of robotics in digestive surgery
(2011)Laparoscopy is widely recognized as feasible and safe approach to many oncologic and benign digestive conditions and is associated with an improved early outcome. Robotic surgery promises to overcome intrinsic limitations ... -
Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies
(2012)Allergic diseases are important concern of public health. A reliable diagnosis is of utmost importance for the management of allergic patients both when immunotherapy is planned and when the treatment is essentially based ... -
Anatomy and surgery of the endoscopic endonasal approach to the skull base
(2012)The midline skull base is an anatomical area, which extends from the anterior limit of the anterior cranial fossa down to the anterior border of the foramen magnum. For many lesions of this area, a variety of skull base ... -
Anesthesiological considerations in shoulder surgery
(2012)In 1970, Winnie proposed the brachial plexus block as an alternative and effective anaesthesia technique for shoulder surgery. From that date, several techniques have been developed to approach the brachial plexus: the use ... -
Aneurysmal subarachnoid haemorrhage in pregnancy: a case series
(2012)Pregnancy is a recognized risk factor for aneurysmal subarachnoid hemorrhage (SAH). Headache is very frequent in normal pregnancy and it is a common sign shared between several intracranial diseases. We present a case ... -
Angiogenesis in Chronic Obstructive Pulmonary Disease: A Translational Appraisal
(2012)Angiogenesis is a crucial component of lung pathophysiology, not only in cancer but also in other disorders, such as chronic obstructive pulmonary disease (COPD). In COPD angiogenesis is definitely able to control and ... -
Autoimmune liver disease: news and perspectives
(2011)Autoimmune liver disorders in childhood include autoimmune hepatitis and autoimmune sclerosing cholangitis. These inflammatory liver disorders are characterised histologically by interface hepatitis, biochemically by ... -
Breakthrough pain: the importance of baseline analgesic regimen with opioids
(2012)Pain is one of the most common and often most feared symptoms in patients with cancer. Ongoing or progressive pain is physically debilitating and has a marked impact on quality of life. During their illness, at least 70% ... -
Carotid and vagal body paragangliomas
(2013)Between 1972 and 2012, 25 patients presenting 32 paragangliomas of the neck were observed. Tumor locations included the carotid body (CBTs) in 21 patients and the vagus nerve in 4. Four patients had bilateral CBT and one ... -
The clinical significance of delirium in the intensive care unit
(2012)Delirium is prevalent among intensive care unit patients. It prolongs length of stay, increases costs, and is independently associated with higher mortality rates. While its specific biological pathways are largely unknown, ... -
The determinants of translational medicine success - A managerial contribution
(2013)Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. Translational medicine represents the synergy between epidemiology, ... -
Dopamine use in intensive care: are we ready to turn it down?
(2012)Dopamine is still frequently used as a first line vasopressor agent in hypotensive patients, when physicians are afraid of noradrenaline and believe that dopamine, with its β and α, inotrope and vasopressor effects, may ... -
Economic evaluation of “pulse dose” radiofrequency in the treatment of occipital neuralgia headache
(2012)Headache occipital neuralgia is an example of pain-disease for which treatment both pharmacological protocols and invasive methods are used. Among the latter, the RF (Radiofrequency) pulse-dose has been of interest for the ... -
Emergency contraception: an updated review
(2011)Emergency contraception is a common practice now. Many categories of drugs are marketed with modifications in dosage, in combination and even in the timing of administration. Recent re-analysis suggests that there is still ... -
End of life in intensive care unit
(2011)